How bad cholesterol blocks arteries found

Scientists claim to have found how bad cholesterol accumulates in the human blood.

A team at the University of New South Wales says that a protein, which directs traffic within cells, is responsible for accumulation of bad cholesterol, a finding which could pave the way for effective treatment for a range of diseases.

Rob Yang, who led the team, said, "Cholesterol is carried around our bloodstream , packaged in particles called lipoproteins.

"Cholesterol from the low-density lipoproteins - also known as bad cholesterol - enters our cells and deposits at different locations through a poorly understood

maze of transport routes." The team found that the protein - Hrs - plays a specific role in directing how and where lowdensity lipoproteins are deposited . They showed how reducing Hrs causes cholesterol to accumulate in endosomes , a cellular compartment usually containing little cholesterol.

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