How bad cholesterol blocks arteries found


Lord of Penmai
Jul 5, 2011
How bad cholesterol blocks arteries found

Scientists claim to have found how bad cholesterol accumulates in the human blood.

A team at the University of New South Wales says that a protein, which directs traffic within cells, is responsible for accumulation of bad cholesterol, a finding which could pave the way for effective treatment for a range of diseases.

Rob Yang, who led the team, said, "Cholesterol is carried around our bloodstream , packaged in particles called lipoproteins.

"Cholesterol from the low-density lipoproteins - also known as bad cholesterol - enters our cells and deposits at different locations through a poorly understood

maze of transport routes." The team found that the protein - Hrs - plays a specific role in directing how and where lowdensity lipoproteins are deposited . They showed how reducing Hrs causes cholesterol to accumulate in endosomes , a cellular compartment usually containing little cholesterol.

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