Stem cell therapy for rheumatoid arthritis

sumitra

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Anyone have idea about stem cell therapy for rheumatoid arthritis?
Hi Sudheesh, please read the following article i am reproducing from the website stemrx.in:

Rheumatoid arthritisis chronic autoimmune systematic inflammatory disease of connective tissue with predominant joint disease of erosive-destructive progressive polyarthritis type. The pathogenesis basis of rheumatoid arthritis consist of genetically determined autoimmune processes, which are caused by deficit of T- suppressor function of lymphocytes.MSCs also display immunosuppressive properties, which suppress local inflammation and tissue damage in inflammatory autoimmune diseases.Stem cells and specifically, mesenchymal stem cells with their immunoregulatory characteristics, differentiation capacity and trophic potential home to inflamed tissue and start producing anti-inflammatory agents. These mediators act locally and do not suppress the immune response of the patient's whole body. Autologous stem cells derived from bone marrow or adipose tissue induce the production of T regulatory cells, a type of immune cell whose function is to protect the body against immunological self-attack.

case history:

A 67 yrs Male patient presented with complaints of pain in Knee joints and Hip joints, deformity, pain and stiffness in all intra carpal & metacarpal joints since 20 years, Post CABG status with LVEF 15 to 20%, Total Knee replacement surgery done for Rt Knee around 15 years back.
Diagnosed as Rheumatoid arthritis, osteoarthritis, AVN both femur heads, IHD in post CABG & Total Knee Replacement done patient.
The patient was treated with
1. Intraarticular Transfusion of Bone Marrow Derived mesenchymal Stem Cells (BMMSCs) in both hip Joints around femur head.
2. Intraarticular Transfusion of BMMSCs in Lt Knee.
3. Intravenous Transfusion of Adipose derived Mesenchymal Stem Cells.
After Stem Cell Therapy patient has shown good improvement in his joint movements, pain has reduced, stiffness of joints in fingers has disappeared and now patient can button his shirt on his own which he is experiencing after twenty year of long suffering.
StemRx team has advised him the diet, life style modification, Physiotherapy and Chine's Traditional Medicine Therapy. Our team is following him for progress.

source: Stem Rx Bio Science Solutions Mumbai
 

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